Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruit flies1–5. However, whether inhibition of mTOR signalling can extend life in a mammalian species was unknown. We report here that rapamycin, an i...

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Detalles Bibliográficos
Autores principales: Harrison, David E., Strong, Randy, Sharp, Zelton Dave, Nelson, James F., Astle, Clinton M., Flurkey, Kevin, Nadon, Nancy L., Wilkinson, J. Erby, Frenkel, Krystyna, Carter, Christy S., Pahor, Marco, Javors, Martin A., Fernandez, Elizabeth, Miller, Richard A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786175/
https://www.ncbi.nlm.nih.gov/pubmed/19587680
http://dx.doi.org/10.1038/nature08221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786175/
https://www.ncbi.nlm.nih.gov/pubmed/19587680
http://dx.doi.org/10.1038/nature08221

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