Cargando…

Topical recombinant thrombin at a concentration of 1000 IU/mL reliably shortens in vivo TTH and delivers durable hemostasis in the presence of heparin anticoagulation and clopidogrel platelet inhibition in a rabbit model of vascular bleeding

BACKGROUND: This study was designed to evaluate the effect of recombinant human thrombin (rThrombin) concentration on time to hemostasis (TTH), clot durability, and clot strength in settings that replicate the heparinization and platelet inhibition often found in surgical populations. METHODS: A mod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hughes, Steven D, Bishop, Paul D, Garcia, Richard, Zhang, Tracy, Alexander, W Allan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786906/ https://www.ncbi.nlm.nih.gov/pubmed/19925675 http://dx.doi.org/10.1186/1750-1164-3-14

Ejemplares similares

A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion-associated phlebitis
por: Saini, Vikas, et al.
Publicado: (2018)

Review of Topical Sodium Heparin 1000 IU/g Gel in Symptomatic Uncomplicated Superficial Thrombophlebitis
por: Cabré, Francesc, et al.
Publicado: (2023)

Anticoagulant properties of enoxaparin 400 IU/mL–40 % ethanol catheter lock solution
por: Calvet, Laure, et al.
Publicado: (2015)

Vitamin D(3) Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals
por: Dědečková, Eva, et al.
Publicado: (2023)

HCV Viral Load Greater Than 1000 IU/ml at Time of Virologic Failure in Direct-Acting Antiviral-Treated Patients
por: Morgan, Jake R., et al.
Publicado: (2021)

Comparative Anticoagulant and Thrombin Generation Inhibitory Profile of Heparin, Sulodexide and Its Components
por: Siddiqui, Fakiha, et al.
Publicado: (2020)

Epidemiology and outcomes of marked elevations of alanine aminotransferase >1000 IU/L in an Australian cohort
por: Con, Danny, et al.
Publicado: (2019)

Evaluation of thrombin generation in dogs administered clopidogrel
por: Rank, Kaitlyn, et al.
Publicado: (2023)

Thrombodynamics—A new global hemostasis assay for heparin monitoring in patients under the anticoagulant treatment
por: Balandina, Anna N., et al.
Publicado: (2018)

Defining the Boundaries of Normal Thrombin Generation: Investigations into Hemostasis
por: Danforth, Christopher M., et al.
Publicado: (2012)

Overall survival of cancer patients with serum lactate dehydrogenase greater than 1000 IU/L
por: Liu, Rujiao, et al.
Publicado: (2016)

The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review
por: Frackiewicz, Aleksandra, et al.
Publicado: (2023)

Omalizumab for the treatment of patients with severe allergic asthma with immunoglobulin E levels above >1500 IU/mL
por: Menzella, Francesco, et al.
Publicado: (2023)

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial
por: Sabico, Shaun, et al.
Publicado: (2021)

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
por: Danckwardt, Sven, et al.
Publicado: (2013)

Use of thrombin generation test for monitoring hemostasis in coronary bypass surgery
por: Gruzdeva, Olga, et al.
Publicado: (2017)

300 IU vs. 200 IU of OnabotulinumtoxinA for detrusor overactivity
por: Persu, Cristian
Publicado: (2014)

Pure Stage I Seminoma with an Elevated hCG of 25,265 mIU/ml: A Case Report
por: Katayama, Hiromichi, et al.
Publicado: (2016)

ADVANCED LIVER INJURY IN PATIENTS WITH CHRONIC HEPATITIS B AND VIRAL LOAD BELOW 2,000 IU/mL
por: de OLIVEIRA, Valter Oberdan Borges, et al.
Publicado: (2016)

Evolutionary Analysis of Pre-S/S Mutations in HBeAg-Negative Chronic Hepatitis B With HBsAg < 100 IU/ml
por: Wu, Yingping, et al.
Publicado: (2021)

Clinical cure rate of inactive HBsAg carriers with HBsAg <200 IU/ml treated with pegylated interferon
por: Li, Hong, et al.
Publicado: (2022)

Natural history of decompensated cirrhosis with serum hepatitis B DNA < 2000 IU/mL: a retrospective study
por: Huang, Xu, et al.
Publicado: (2022)

Anticoagulants and the Propagation Phase of Thrombin Generation
por: Orfeo, Thomas, et al.
Publicado: (2011)

Hemostasis, coagulation and thrombin in venoarterial and venovenous extracorporeal membrane oxygenation: the HECTIC study
por: Cartwright, Bruce, et al.
Publicado: (2021)

Thrombin generation, bleeding and hemostasis in humans: Protocol for a scoping review of the literature
por: Shaw, Joseph R., et al.
Publicado: (2023)

Polydopamine-Coated Polycaprolactone Electrospun Nanofiber Membrane Loaded with Thrombin for Wound Hemostasis
por: Cui, Dapeng, et al.
Publicado: (2023)

Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis
por: Grover, Steven P., et al.
Publicado: (2022)

Thrombin Decrease in Thrombin Generation after Heparin Administration in a Homozygous Type II Heparin-Binding Site Antithrombin-Deficient Pregnant Woman
por: Malíková, Ivana, et al.
Publicado: (2023)

Predictive value of FibroScan in detecting liver fibrosis in HBeAg negative patients with chronic hepatitis B whose HBV DNA 2000–20000 IU/ml with ALT 1–2 times the upper limit of normal and those with HBV DNA >20000 IU/ml and normal ALT
por: Danis, Nilay, et al.
Publicado: (2021)

Cardiac Murmurs Iu Chorea
Publicado: (1871)

RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A
por: Lin, Wen-yi, et al.
Publicado: (2021)

Conservative Management of Interstitial Pregnancy With Beta-hCG of Over 39,000 mIU/mL: A Case Report
por: Mayuga, Tom J, et al.
Publicado: (2022)

Thrombin based gelatin matrix and fibrin sealant mediated clot formation in the presence of clopidogrel
por: Dwyer, Joseph F, et al.
Publicado: (2014)

Heparin or nonheparin anticoagulants for VITT
por: Arnold, Donald M.
Publicado: (2022)

No effect of monthly supplementation with 12000 IU, 24000 IU or 48000 IU vitamin D3 for one year on muscle function: The vitamin D in older people study
por: Ranathunga, R.M.T.K., et al.
Publicado: (2019)

Hemostasis during low molecular weight heparin anticoagulation for continuous venovenous hemofiltration: a randomized cross-over trial comparing two hemofiltration rates
por: Oudemans-van Straaten, Heleen M, et al.
Publicado: (2009)

Thrombin Generation Biomarkers Decline With Parenteral Anticoagulation—An Overlooked Means of Anticoagulation Monitoring?
por: McFarland, Craig P., et al.
Publicado: (2018)

ttH at the LHC
por: Madaffari, Daniele
Publicado: (2018)

Prospects for ttH
por: Allwood-Spiers, S
Publicado: (2011)

Incidence and predictors of HBV relapse after cessation of nucleoside analogues in HBeAg-negative patients with HBsAg ≤ 200 IU/mL
por: Yao, Chih-Chien, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t2eb0ikslq0jgm0r1mitfl2q3u