Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog RT drugs. We determined the crystal structures of K65R mutant RT cross-linked to...

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Detalles Bibliográficos
Autores principales: Das, Kalyan, Bandwar, Rajiv P., White, Kirsten L., Feng, Joy Y., Sarafianos, Stefan G., Tuske, Steven, Tu, Xiongying, Clark, Arthur D., Boyer, Paul L., Hou, Xiaorong, Gaffney, Barbara L., Jones, Roger A., Miller, Michael D., Hughes, Stephen H., Arnold, Eddy
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787370/
https://www.ncbi.nlm.nih.gov/pubmed/19812032
http://dx.doi.org/10.1074/jbc.M109.022525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787370/
https://www.ncbi.nlm.nih.gov/pubmed/19812032
http://dx.doi.org/10.1074/jbc.M109.022525

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