Adaptive Suppression of the ATF4-CHOP Branch of the Unfolded Protein Response by Toll-Like Receptor Signaling

The endoplasmic reticulum (ER) Unfolded Protein Response (UPR) restores equilibrium to the ER, but prolonged expression of the UPR effector CHOP (GADD153) is cytotoxic. We found that ER stress-induced CHOP expression was suppressed by prior engagement of toll-like receptor (TLR) 3 or 4 through a TRI...

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Detalles Bibliográficos
Autores principales: Woo, Connie W., Cui, Dongying, Arellano, Jerry, Dorweiler, Bernhard, Harding, Heather, Fitzgerald, Katherine A., Ron, David, Tabas, Ira
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787632/
https://www.ncbi.nlm.nih.gov/pubmed/19855386
http://dx.doi.org/10.1038/ncb1996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787632/
https://www.ncbi.nlm.nih.gov/pubmed/19855386
http://dx.doi.org/10.1038/ncb1996

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