Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress

Hyperinsulinemia associated with type II diabetes mellitus is a risk factor for non-alcoholic steatohepatitis (NASH) and hepatic fibrosis. Hepatic stellate cells (HSCs) are the major effectors in collagen production during hepatic fibrogenesis. Elevated levels of insulin stimulate HSC activation. In...

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Detalles Bibliográficos
Autores principales: Lin, Jianguo, Zheng, Shizhong, Chen, Anping
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787823/
https://www.ncbi.nlm.nih.gov/pubmed/19841616
http://dx.doi.org/10.1038/labinvest.2009.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787823/
https://www.ncbi.nlm.nih.gov/pubmed/19841616
http://dx.doi.org/10.1038/labinvest.2009.115

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