A Wnt-kinase network alters nuclear localization of TCF-1 in colon cancer

Constitutive activation of the Wnt/β-catenin pathway has been implicated as the primary cause of colon cancer. However, the major transducers of Wnt signaling in the intestine, TCF-1 and TCF-4, have opposing functions. Knock-out of TCF-4 suppresses growth and maintenance of crypt stem cells, while k...

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Detalles Bibliográficos
Autores principales: Najdi, Rani, Syed, Adeela, Arce, Laura, Theisen, Heidi, Ting, Ju-Hui T., Atcha, Fawzia, Nguyen, Anthony V., Martinez, Micaela, Holcombe, Randall F., Edwards, Robert A., Marsh, J. Lawrence, Waterman, Marian L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787979/
https://www.ncbi.nlm.nih.gov/pubmed/19749792
http://dx.doi.org/10.1038/onc.2009.271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787979/
https://www.ncbi.nlm.nih.gov/pubmed/19749792
http://dx.doi.org/10.1038/onc.2009.271

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