Cargando…

A Wnt-kinase network alters nuclear localization of TCF-1 in colon cancer

Constitutive activation of the Wnt/β-catenin pathway has been implicated as the primary cause of colon cancer. However, the major transducers of Wnt signaling in the intestine, TCF-1 and TCF-4, have opposing functions. Knock-out of TCF-4 suppresses growth and maintenance of crypt stem cells, while k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Najdi, Rani, Syed, Adeela, Arce, Laura, Theisen, Heidi, Ting, Ju-Hui T., Atcha, Fawzia, Nguyen, Anthony V., Martinez, Micaela, Holcombe, Randall F., Edwards, Robert A., Marsh, J. Lawrence, Waterman, Marian L.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787979/ https://www.ncbi.nlm.nih.gov/pubmed/19749792 http://dx.doi.org/10.1038/onc.2009.271

Ejemplares similares

Wnt signaling and colon carcinogenesis: Beyond APC
por: Najdi, Rani, et al.
Publicado: (2011)

Wingless Directly Represses DPP Morphogen Expression via an Armadillo/TCF/Brinker Complex
por: Theisen, Heidi, et al.
Publicado: (2007)

Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption
por: Holcombe, Randall F., et al.
Publicado: (2015)

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition
por: Hoverter, Nate P., et al.
Publicado: (2014)

Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
por: Nguyen, Anthony V, et al.
Publicado: (2009)

Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer
por: Lee, Mary, et al.
Publicado: (2017)

Past Visits Present: TCF/LEFs Partner with ATFs for β-Catenin–Independent Activity
por: Sprowl, Stephanie, et al.
Publicado: (2013)

Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion
por: Planutiene, Marina, et al.
Publicado: (2011)

Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells
por: Planutis, Kestutis, et al.
Publicado: (2007)

Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells
por: Hrckulak, Dusan, et al.
Publicado: (2018)

The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas
por: Tiemessen, Machteld M., et al.
Publicado: (2012)

Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal
por: Yi, Fei, et al.
Publicado: (2011)

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas
por: Varnat, Frédéric, et al.
Publicado: (2010)

Dazap2 modulates transcription driven by the Wnt effector TCF-4
por: Lukas, Jan, et al.
Publicado: (2009)

Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates
por: Torres‐Aguila, Nuria P., et al.
Publicado: (2022)

Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer
por: Sprowl-Tanio, Stephanie, et al.
Publicado: (2016)

Invasive colon cancer, but not non-invasive adenomas induce a gradient effect of Wnt pathway receptor frizzled 1 (Fz1) expression in the tumor microenvironment
por: Planutis, Kestutis, et al.
Publicado: (2013)

Regulation of asymmetric positioning of nuclei by Wnt and Src signaling and its roles in POP-1/TCF nuclear asymmetry in Caenorhabditis elegans
por: Sugioka, Kenji, et al.
Publicado: (2010)

Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells
por: Wenzel, Janna, et al.
Publicado: (2020)

Multi-Level Interactions between the Nuclear Receptor TRα1 and the WNT Effectors β-Catenin/Tcf4 in the Intestinal Epithelium
por: Sirakov, Maria, et al.
Publicado: (2012)

The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease
por: Sameni, Sara, et al.
Publicado: (2016)

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling
por: Schepeler, Troels, et al.
Publicado: (2007)

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression
por: Wallmen, Britta, et al.
Publicado: (2012)

Correction: Multi-Level Interactions between the Nuclear Receptor TRα1 and the WNT Effectors β-Catenin/Tcf4 in the Intestinal Epithelium
Publicado: (2014)

Retraction: Multi-Level Interactions between the Nuclear Receptor TRα1 and the WNT Effectors β-Catenin/Tcf4 in the Intestinal Epithelium
Publicado: (2020)

Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease
por: Koslowski, Maureen J., et al.
Publicado: (2009)

Temporal Perturbation of the Wnt Signaling Pathway in the Control of Cell Reprogramming Is Modulated by TCF1
por: Aulicino, Francesco, et al.
Publicado: (2014)

Wnt-Mediated Repression via Bipartite DNA Recognition by TCF in the Drosophila Hematopoietic System
por: Zhang, Chen U., et al.
Publicado: (2014)

Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling
por: Ravindranath, Aditi, et al.
Publicado: (2014)

A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators
por: Freeman, Jamie, et al.
Publicado: (2015)

Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma
por: Ishiguro, Hideyuki, et al.
Publicado: (2016)

A novel signaling pathway regulates colon cancer angiogenesis through Norrin
por: Planutis, Kestutis, et al.
Publicado: (2014)

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction
por: Gan, Xiao-qing, et al.
Publicado: (2008)

Correction: Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling
Publicado: (2014)

Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
por: Song, Yonghee, et al.
Publicado: (2018)

Narrowband UVB treatment induces expression of WNT7B, WNT10B and TCF7L2 in psoriasis skin
por: Assarsson, Malin, et al.
Publicado: (2019)

Inhibition of Tcf-4 Induces Apoptosis and Enhances Chemosensitivity of Colon Cancer Cells
por: Xie, Jiang, et al.
Publicado: (2012)

A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12
por: Duquet, Arnaud, et al.
Publicado: (2014)

The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases
por: Mishra, Sonakshi, et al.
Publicado: (2019)

Wnt–β-catenin–Tcf-4 signalling-modulated invasiveness is dependent on osteopontin expression in breast cancer
por: Ravindranath, A, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6d5kqdvu64upvgn7cefokf52k0