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Physiochemical property space distribution among human metabolites, drugs and toxins
BACKGROUND: The current approach to screen for drug-like molecules is to sieve for molecules with biochemical properties suitable for desirable pharmacokinetics and reduced toxicity, using predominantly biophysical properties of chemical compounds, based on empirical rules such as Lipinski's &q...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788350/ https://www.ncbi.nlm.nih.gov/pubmed/19958509 http://dx.doi.org/10.1186/1471-2105-10-S15-S10 |