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Physiochemical property space distribution among human metabolites, drugs and toxins

BACKGROUND: The current approach to screen for drug-like molecules is to sieve for molecules with biochemical properties suitable for desirable pharmacokinetics and reduced toxicity, using predominantly biophysical properties of chemical compounds, based on empirical rules such as Lipinski's &q...

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Detalles Bibliográficos
Autores principales: Khanna, Varun, Ranganathan, Shoba
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788350/
https://www.ncbi.nlm.nih.gov/pubmed/19958509
http://dx.doi.org/10.1186/1471-2105-10-S15-S10

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