Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

BACKGROUND: The tumor suppressor protein p53 is regulated by the ubiquitin ligase MDM2 which down-regulates p53. In tumours with overexpressed MDM2, the p53-MDM2 interaction can be interrupted by a peptide or small molecule to stabilize p53 as a therapeutic strategy. Structural and biochemical/mutag...

Descripción completa

Detalles Bibliográficos
Autores principales: Dastidar, Shubhra Ghosh, Lane, David P, Verma, Chandra S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788357/
https://www.ncbi.nlm.nih.gov/pubmed/19958516
http://dx.doi.org/10.1186/1471-2105-10-S15-S6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788357/
https://www.ncbi.nlm.nih.gov/pubmed/19958516
http://dx.doi.org/10.1186/1471-2105-10-S15-S6

Ejemplares similares