Cargando…

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

BACKGROUND: The tumor suppressor protein p53 is regulated by the ubiquitin ligase MDM2 which down-regulates p53. In tumours with overexpressed MDM2, the p53-MDM2 interaction can be interrupted by a peptide or small molecule to stabilize p53 as a therapeutic strategy. Structural and biochemical/mutag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dastidar, Shubhra Ghosh, Lane, David P, Verma, Chandra S
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788357/ https://www.ncbi.nlm.nih.gov/pubmed/19958516 http://dx.doi.org/10.1186/1471-2105-10-S15-S6

Ejemplares similares

C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms
por: Brown, Christopher J., et al.
Publicado: (2011)

Stability of the core domain of p53: insights from computer simulations
por: Madhumalar, Arumugam, et al.
Publicado: (2008)

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2019)

Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
por: Yadahalli, Shilpa, et al.
Publicado: (2017)

Circles within circles: crosstalk between protein Ser/Thr/Tyr-phosphorylation and Met oxidation
por: Rao, R Shyama Prasad, et al.
Publicado: (2013)

Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2
por: Yadahalli, Shilpa, et al.
Publicado: (2019)

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
por: Coffill, Cynthia R., et al.
Publicado: (2016)

Dynamics of Bcl-xL in Water and Membrane: Molecular Simulations
por: Maity, Atanu, et al.
Publicado: (2013)

Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases
por: Vinekar, Rithvik, et al.
Publicado: (2012)

Computing the protein binding sites
por: Guo, Fei, et al.
Publicado: (2012)

Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction
por: Thayer, Kelly M., et al.
Publicado: (2016)

p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX
por: Levy, Robin, et al.
Publicado: (2019)

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish
por: Chua, J S, et al.
Publicado: (2015)

Computational gene network analysis reveals TNF-induced angiogenesis
por: Ogami, Kentaro, et al.
Publicado: (2012)

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53
por: Wong, Jin Huei, et al.
Publicado: (2017)

Modelling study of dimerization in mammalian defensins
por: Suresh, Anita, et al.
Publicado: (2006)

Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors
por: Yanamala, Naveena, et al.
Publicado: (2008)

Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci
por: Frosi, Y., et al.
Publicado: (2019)

Computational annotation of UTR cis-regulatory modules through Frequent Pattern Mining
por: Turi, Antonio, et al.
Publicado: (2009)

Functional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells
por: Nakagawa, Mayu, et al.
Publicado: (2022)

Computational identification of genetic subnetwork modules associated with maize defense response to Fusarium verticillioides
por: Kim, Mansuck, et al.
Publicado: (2015)

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation
por: Drummond, Catherine J., et al.
Publicado: (2016)

The C-terminus of p53 binds the N-terminal domain of MDM2
por: Poyurovsky, Masha V., et al.
Publicado: (2010)

mRNA Display Selection of an Optimized MDM2-Binding Peptide That Potently Inhibits MDM2-p53 Interaction
por: Shiheido, Hirokazu, et al.
Publicado: (2011)

Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4
por: Vaas, Sebastian, et al.
Publicado: (2023)

DNA-binding residues and binding mode prediction with binding-mechanism concerned models
por: Huang, Yu-Feng, et al.
Publicado: (2009)

MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation
por: Hirose, Mitsuaki, et al.
Publicado: (2014)

S100A1 blocks the interaction between p53 and mdm2 and decreases cell proliferation activity
por: Dowarha, Deepu, et al.
Publicado: (2020)

Regulation of p53: a collaboration between Mdm2 and MdmX
por: Pei, Dongsheng, et al.
Publicado: (2012)

Regulation of kidney development by the Mdm2/Mdm4–p53 axis
por: El-Dahr, Samir, et al.
Publicado: (2017)

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
por: Mrkvová, Zuzana, et al.
Publicado: (2019)

Structural Basis for Inhibition of the MDM2:p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display
por: Nagata, Takashi, et al.
Publicado: (2014)

Tau protein binds to the P53 E3 ubiquitin ligase MDM2
por: Sola, Martina, et al.
Publicado: (2023)

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
por: Yuen, Tsz Ying, et al.
Publicado: (2019)

Tissue microarrays: applications in study of p16 and p53 alterations in Ewing's cell lines
por: Noguera, Rosa, et al.
Publicado: (2008)

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket
por: Pradhan, Mohan R, et al.
Publicado: (2019)

Detection of P53 and Mdm2 in vitiligo
por: Wiwanitkit, Viroj
Publicado: (2013)

The MDM2-p53 pathway revisited
por: Nag, Subhasree, et al.
Publicado: (2013)

Evolution of the p53-MDM2 pathway
por: Åberg, Emma, et al.
Publicado: (2017)

Importance of lactic acid bacteria in Asian fermented foods
por: Rhee, Sook Jong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_c3c3rmsibsd99jcfjeqfq8eph9