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The Use of Knockout Mice Reveals a Synergistic Role of the Vav1 and Rasgrf2 Gene Deficiencies in Lymphomagenesis and Metastasis
BACKGROUND: Vav1 and RasGRF2 are GDP/GTP exchange factors for Ras superfamily GTPases with roles in the development and/or effector functions of T–lymphocytes. METHODOLOGY/PRINCIPAL FINDINGS: Given that the phenotype of Vav1 (–/–), Rasgrf2 (–/–) and Vav1 (–/–);Rasgrf2 (–/–) mice has been studied so...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788417/ https://www.ncbi.nlm.nih.gov/pubmed/20011522 http://dx.doi.org/10.1371/journal.pone.0008229 |