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Patterned Neuroprotection in the Inpp4a(wbl) Mutant Mouse Cerebellum Correlates with the Expression of Eaat4

The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell loss is a common pathological finding in many...

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Detalles Bibliográficos
Autores principales: Sachs, Andrew J., David, Samuel A., Haider, Neena B., Nystuen, Arne M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788419/
https://www.ncbi.nlm.nih.gov/pubmed/20011524
http://dx.doi.org/10.1371/journal.pone.0008270