The Chaperonin TRIC Blocks a Huntingtin Sequence Element that promotes the Conformational Switch to Aggregation

Aggregation of proteins containing polyglutamine (polyQ) expansions characterizes many neurodegenerative disorders, including Huntington’s disease. Molecular chaperones modulate Huntingtin (Htt) aggregation and toxicity by an ill-defined mechanism. Here we determine how the chaperonin TRiC suppresse...

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Detalles Bibliográficos
Autores principales: Tam, Stephen, Spiess, Christoph, Auyeung, William, Joachimiak, Lukasz, Chen, Bryan, Poirier, Michelle A., Frydman, Judith
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788664/
https://www.ncbi.nlm.nih.gov/pubmed/19915590
http://dx.doi.org/10.1038/nsmb.1700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788664/
https://www.ncbi.nlm.nih.gov/pubmed/19915590
http://dx.doi.org/10.1038/nsmb.1700

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