Mutant Fibroblast Growth Factor Receptor 3 Induces Intracellular Signaling and Cellular Transformation in a Cell Type- and Mutation-Specific Manner

Although activating mutations of FGFR3 are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mutation spectrum. We investigated the phenotypic and signaling consequences of three FGFR3 mutations (S249C, Y375C, and...

Descripción completa

Detalles Bibliográficos
Autores principales: di Martino, E, L'Hôte, CG, Kennedy, W, Tomlinson, DC, Knowles, MA
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789045/
https://www.ncbi.nlm.nih.gov/pubmed/19749790
http://dx.doi.org/10.1038/onc.2009.280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789045/
https://www.ncbi.nlm.nih.gov/pubmed/19749790
http://dx.doi.org/10.1038/onc.2009.280

Ejemplares similares