Cargando…

The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase

BACKGROUND: The shikimate pathway is an attractive target for the development of antitubercular agents because it is essential in Mycobacterium tuberculosis, the causative agent of tuberculosis, but absent in humans. M. tuberculosis aroE-encoded shikimate dehydrogenase catalyzes the forth reaction i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodrigues, Valnês S, Breda, Ardala, Santos, Diógenes S, Basso, Luiz A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789096/ https://www.ncbi.nlm.nih.gov/pubmed/19917104 http://dx.doi.org/10.1186/1756-0500-2-227

Ejemplares similares

Development of Mycobacterium tuberculosis attenuated strains as live vaccine candidates for tuberculosis
por: Villela, Anne, et al.
Publicado: (2014)

The Mode of Action of Recombinant Mycobacterium tuberculosis Shikimate Kinase: Kinetics and Thermodynamics Analyses
por: Rosado, Leonardo Astolfi, et al.
Publicado: (2013)

Wild-Type Phosphoribosylpyrophosphate Synthase (PRS) from Mycobacterium tuberculosis: A Bacterial Class II PRS?
por: Breda, Ardala, et al.
Publicado: (2012)

Functional Analysis of 3-Dehydroquinate Dehydratase/Shikimate Dehydrogenases Involved in Shikimate Pathway in Camellia sinensis
por: Huang, Keyi, et al.
Publicado: (2019)

Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs
por: Nunes, José E. S., et al.
Publicado: (2020)

Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli
por: Díaz-Quiroz, Dulce Catalina, et al.
Publicado: (2018)

Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia
por: Yuan, Junwei, et al.
Publicado: (2022)

Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials
por: Gordon, Sara, et al.
Publicado: (2015)

Downregulation of Brassica napus MYB69 (BnMYB69) increases biomass growth and disease susceptibility via remodeling phytohormone, chlorophyll, shikimate and lignin levels
por: Lin, Na, et al.
Publicado: (2023)

Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments
por: Freitas de Freitas, Talita, et al.
Publicado: (2022)

Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth
por: Villela, Anne Drumond, et al.
Publicado: (2015)

Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases
por: Swanson, Christopher R. B., et al.
Publicado: (2023)

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages
por: Villela, Anne Drumond, et al.
Publicado: (2017)

Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis
por: Villela, Anne Drumond, et al.
Publicado: (2017)

Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase
por: Tseliou, Vasilis, et al.
Publicado: (2019)

An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway
por: Frlan, Rok
Publicado: (2022)

Shikimic acid : metabolism and metabolites
por: Haslam, Edwin
Publicado: (1993)

Determination of the Cytosolic NADPH/NADP Ratio in Saccharomyces cerevisiae using Shikimate Dehydrogenase as Sensor Reaction
por: Zhang, Jinrui, et al.
Publicado: (2015)

Inhibition and Biochemical Characterization of Methicillin-Resistant Staphylococcus aureus Shikimate Dehydrogenase: An in Silico and Kinetic Study
por: Avitia-Domínguez, Claudia, et al.
Publicado: (2014)

Elucidating the role of shikimate dehydrogenase in controlling the production of anthocyanins and hydrolysable tannins in the outer peels of pomegranate
por: Habashi, Rida, et al.
Publicado: (2019)

Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis
por: Tahara, Ko, et al.
Publicado: (2020)

Two shikimate dehydrogenases, VvSDH3 and VvSDH4, are involved in gallic acid biosynthesis in grapevine
por: Bontpart, Thibaut, et al.
Publicado: (2016)

Tris[(6S)-6-hydroxy-4-epi-shikimic acid] monohydrate: an enantiomerically pure hydroxylated shikimic acid derived from methyl shikimate
por: Griesbeck, Axel G., et al.
Publicado: (2012)

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates
por: Nanna, Alex R., et al.
Publicado: (2017)

Shikimate and Phenylalanine Biosynthesis in the Green Lineage
por: Tohge, Takayuki, et al.
Publicado: (2013)

Increased Glyphosate-Induced Gene Expression in the Shikimate Pathway Is Abolished in the Presence of Aromatic Amino Acids and Mimicked by Shikimate
por: Zulet-González, Ainhoa, et al.
Publicado: (2020)

Enzymatic Activity Analysis and Catalytic Essential Residues Identification of Brucella abortus Malate Dehydrogenase
por: Han, Xiangan, et al.
Publicado: (2014)

Targeted Mutation of a Non-catalytic Gating Residue Increases the Rate of Pseudomonas aeruginosad-Arginine Dehydrogenase Catalytic Turnover
por: Quaye, Joanna Afokai, et al.
Publicado: (2023)

Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects
por: Wu, Sijia, et al.
Publicado: (2022)

Isolation of alpha-linolenic acid from Sutherlandia frutescens and its inhibition of Mycobacterium tuberculosis’ shikimate kinase enzyme
por: Masoko, Peter, et al.
Publicado: (2016)

Discrimination of Bacillus subtilis from Other Bacillus Species Using Specific Oligonucleotide Primers for the Pyruvate Carboxylase and Shikimate Dehydrogenase Genes
por: Lee, Gawon, et al.
Publicado: (2022)

Voltage-gated Na Channel Selectivity: The Role of the Conserved Domain III Lysine Residue
por: Lipkind, Gregory M., et al.
Publicado: (2008)

Shikimate Metabolic Pathway Engineering in Corynebacterium glutamicum
por: Park, Eunhwi, et al.
Publicado: (2021)

An evolutionary analysis identifies a conserved pentapeptide stretch containing the two essential lysine residues for rice L-myo-inositol 1-phosphate synthase catalytic activity
por: Basak, Papri, et al.
Publicado: (2017)

Catalytic and Functional Roles of Conserved Amino Acids in the SET Domain of the S. cerevisiae Lysine Methyltransferase Set1
por: Williamson, Kelly, et al.
Publicado: (2013)

Lysines K117 and K147 play conserved roles in Ras activation from Drosophila to mammals
por: Singh, Jiya, et al.
Publicado: (2023)

Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme
por: Martinelli, Leonardo K. B., et al.
Publicado: (2017)

The roles of highly conserved, non‐catalytic residues in class A β‐lactamases
por: Chikunova, Aleksandra, et al.
Publicado: (2022)

Evolutionary Diversification of Plant Shikimate Kinase Gene Duplicates
por: Fucile, Geoffrey, et al.
Publicado: (2008)

SKPDB: a structural database of shikimate pathway enzymes
por: Arcuri, Helen A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_782otaferg3lof28u3tb4sa3ji