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Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

The enzyme myristoyl-CoA:protein N-myristoyltransferase (NMT) catalyses the co-translational covalent attachment of the fatty acid myristate to the N-terminus of target proteins. NMT is known to be essential for viability in Trypanosoma brucei and Leishmania major. Here we describe phenotypic analys...

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Detalles Bibliográficos
Autores principales:	Price, Helen P., Güther, M. Lucia S., Ferguson, Michael A.J., Smith, Deborah F.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier/North-Holland Biomedical Press 2010
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789243/ https://www.ncbi.nlm.nih.gov/pubmed/19782106 http://dx.doi.org/10.1016/j.molbiopara.2009.09.006

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