The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

Neuregulin-1 (NRG1) is both a candidate oncogene and candidate tumour suppressor gene. It encodes the heregulins and other mitogenic ligands for the ERBB family, but it also causes apoptosis in NRG1-expressing cells. We found that most breast cancer cell lines had reduced or undetectable expression...

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Detalles Bibliográficos
Autores principales: Chua, YL, Ito, Y, Pole, JCM, Newman, S, Chin, S-F, Stein, RC, Ellis, IO, Caldas, C, O’Hare, MJ, Murrell, A, Edwards, PAW
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789334/
https://www.ncbi.nlm.nih.gov/pubmed/19802002
http://dx.doi.org/10.1038/onc.2009.259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789334/
https://www.ncbi.nlm.nih.gov/pubmed/19802002
http://dx.doi.org/10.1038/onc.2009.259

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