A Transition Path Ensemble Study Reveals a Linchpin Role for Mg(2+) during Rate-Limiting ADP Release from Protein Kinase A

[Image: see text] Protein kinases are key regulators of diverse signaling networks critical for growth and development. Protein kinase A (PKA) is an important kinase prototype that phosphorylates protein targets at Ser and Thr residues by converting ATP to ADP. Mg(2+) ions play a crucial role in reg...

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Detalles Bibliográficos
Autores principales: Khavrutskii, Ilja V., Grant, Barry, Taylor, Susan S., McCammon, J. Andrew
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789581/
https://www.ncbi.nlm.nih.gov/pubmed/19886670
http://dx.doi.org/10.1021/bi901475g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789581/
https://www.ncbi.nlm.nih.gov/pubmed/19886670
http://dx.doi.org/10.1021/bi901475g

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