Cargando…
A Transition Path Ensemble Study Reveals a Linchpin Role for Mg(2+) during Rate-Limiting ADP Release from Protein Kinase A
[Image: see text] Protein kinases are key regulators of diverse signaling networks critical for growth and development. Protein kinase A (PKA) is an important kinase prototype that phosphorylates protein targets at Ser and Thr residues by converting ATP to ADP. Mg(2+) ions play a crucial role in reg...
| Autores principales: | , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2009
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789581/ https://www.ncbi.nlm.nih.gov/pubmed/19886670 http://dx.doi.org/10.1021/bi901475g |