Dopamine D2 Receptor Stimulation Potentiates PolyQ-Huntingtin-Induced Mouse Striatal Neuron Dysfunctions via Rho/ROCK-II Activation

BACKGROUND: Huntington's disease (HD) is a polyglutamine-expanded related neurodegenerative disease. Despite the ubiquitous expression of expanded, polyQ-Huntingtin (ExpHtt) in the brain, striatal neurons present a higher susceptibility to the mutation. A commonly admitted hypothesis is that Do...

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Detalles Bibliográficos
Autores principales: Deyts, Carole, Galan-Rodriguez, Beatriz, Martin, Elodie, Bouveyron, Nicolas, Roze, Emmanuel, Charvin, Delphine, Caboche, Jocelyne, Bétuing, Sandrine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790370/
https://www.ncbi.nlm.nih.gov/pubmed/20016831
http://dx.doi.org/10.1371/journal.pone.0008287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790370/
https://www.ncbi.nlm.nih.gov/pubmed/20016831
http://dx.doi.org/10.1371/journal.pone.0008287

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