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Dopamine D2 Receptor Stimulation Potentiates PolyQ-Huntingtin-Induced Mouse Striatal Neuron Dysfunctions via Rho/ROCK-II Activation
BACKGROUND: Huntington's disease (HD) is a polyglutamine-expanded related neurodegenerative disease. Despite the ubiquitous expression of expanded, polyQ-Huntingtin (ExpHtt) in the brain, striatal neurons present a higher susceptibility to the mutation. A commonly admitted hypothesis is that Do...
Autores principales: | Deyts, Carole, Galan-Rodriguez, Beatriz, Martin, Elodie, Bouveyron, Nicolas, Roze, Emmanuel, Charvin, Delphine, Caboche, Jocelyne, Bétuing, Sandrine |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790370/ https://www.ncbi.nlm.nih.gov/pubmed/20016831 http://dx.doi.org/10.1371/journal.pone.0008287 |
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