Cargando…

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease

The amyloid-β 42 (Aβ42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which Aβ42 induces neuronal dysfunction and degeneration remain elusive. Mitochondrial dysfunctions are implicated in AD brains. Whether mitochondrial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iijima-Ando, Kanae, Hearn, Stephen A., Shenton, Christopher, Gatt, Anthony, Zhao, LiJuan, Iijima, Koichi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790372/ https://www.ncbi.nlm.nih.gov/pubmed/20016833 http://dx.doi.org/10.1371/journal.pone.0008310

Ejemplares similares

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila
por: Iijima, Koichi, et al.
Publicado: (2008)

Regulation of Energy Stores and Feeding by Neuronal and Peripheral CREB Activity in Drosophila
por: Iijima, Koichi, et al.
Publicado: (2009)

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models
por: Sekiya, Michiko, et al.
Publicado: (2018)

Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila
por: Oka, Mikiko, et al.
Publicado: (2021)

Phenotypic analysis of a transgenic Drosophila model of Alzheimer’s amyloid-β toxicity
por: Sekiya, Michiko, et al.
Publicado: (2021)

Dissecting the daily feeding pattern: Peripheral CLOCK/CYCLE generate the feeding/fasting episodes and neuronal molecular clocks synchronize them
por: Maruko, Akiko, et al.
Publicado: (2023)

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity
por: Ando, Kanae, et al.
Publicado: (2016)

Physiological Mouse Brain Aβ Levels Are Not Related to the Phosphorylation State of Threonine-668 of Alzheimer's APP
por: Sano, Yoshitake, et al.
Publicado: (2006)

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1
por: Iijima-Ando, Kanae, et al.
Publicado: (2012)

Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons
por: Natarajaseenivasan, Kalimuthusamy, et al.
Publicado: (2020)

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila
por: Sakakibara, Yasufumi, et al.
Publicado: (2018)

New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis
por: Theunissen, Frances, et al.
Publicado: (2021)

Degradative organelles containing mislocalized α- and β-synuclein proliferate in presenilin-1 null neurons
por: Wilson, Christina A., et al.
Publicado: (2004)

Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment
por: Rossi, Chiara, et al.
Publicado: (2021)

5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila
por: Nozawa, Naoko, et al.
Publicado: (2021)

5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila
por: Nozawa, Naoko, et al.
Publicado: (2023)

Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
por: Llamusi, Beatriz, et al.
Publicado: (2013)

Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
por: Irazoki, Andrea, et al.
Publicado: (2023)

Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins
por: Claypool, Steven M., et al.
Publicado: (2006)

The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains
por: Oyarce-Pezoa, Sebastián, et al.
Publicado: (2023)

The Role of Temporal Information in Perisaccadic Mislocalization
por: Matziridi, Maria, et al.
Publicado: (2015)

The Protein Subcellular Mislocalization in Human Cancers
por: Ghaemimanesh, Fatemeh
Publicado: (2020)

Mislocalization after inhibition of saccadic adaptation
por: Heins, Frauke, et al.
Publicado: (2022)

Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
por: Whiteley, Alexandra M, et al.
Publicado: (2017)

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons
por: Lange, Jenny, et al.
Publicado: (2021)

The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease
por: Lee, Soojin, et al.
Publicado: (2016)

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
por: Kerr, F., et al.
Publicado: (2011)

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease
por: Sakakibara, Yasufumi, et al.
Publicado: (2019)

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila
por: Rogers, Iain, et al.
Publicado: (2012)

CSF Aβ42 and Aβ42/Aβ40 Ratio in Alzheimer’s Disease and Frontotemporal Dementias
por: Constantinides, Vasilios C., et al.
Publicado: (2023)

Neuronal SAM68 differentially regulates alternative last exon splicing and ensures proper synapse development and function
por: Darwish, Mohamed, et al.
Publicado: (2023)

Phenotypic differences between Drosophila Alzheimer’s disease models expressing human Aβ42 in the developing eye and brain
por: Jeon, Youngjae, et al.
Publicado: (2017)

Exogenous expression of Drp1 plays neuroprotective roles in the Alzheimer's disease in the Aβ42 transgenic Drosophila model
por: Lv, Fengshou, et al.
Publicado: (2017)

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS
por: Tyzack, Giulia E, et al.
Publicado: (2020)

Proteome-wide discovery of mislocated proteins in cancer
por: Lee, KiYoung, et al.
Publicado: (2013)

Visual Mislocalization of Moving Objects in an Audiovisual Event
por: Kawachi, Yousuke
Publicado: (2016)

Inflammation Induces TDP-43 Mislocalization and Aggregation
por: Correia, Ana Sofia, et al.
Publicado: (2015)

Visual mislocalization during double-step saccades
por: Zimmermann, Eckart
Publicado: (2015)

BC RNA Mislocalization in the Fragile X Premutation
por: Muslimov, Ilham A., et al.
Publicado: (2018)

Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau
por: Dickson, John R, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hm33pthifsbapq9pcc5opr7l74