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Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats

Brain function declines with age and is associated with diminishing mitochondrial integrity. The neuronal mitochondrial ultrastructural changes of young (4 months) and old (21 months) F344 rats supplemented with two mitochondrial metabolites, acetyl-L-carnitine (ALCAR, 0.2%[wt/vol] in the drinking w...

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Detalles Bibliográficos
Autores principales: Aliev, Gjumrakch, Liu, Jiankang, Shenk, Justin C, Fischbach, Kathryn, Pacheco, Gerardo J, Chen, Shu G, Obrenovich, Mark E, Ward, Walter F, Richardson, Arlan G, Smith, Mark A, Gasimov, Eldar, Perry, George, Ames, Bruce N
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790425/
https://www.ncbi.nlm.nih.gov/pubmed/18373733
http://dx.doi.org/10.1111/j.1582-4934.2008.00324.x