Global Demethylation of Rat Chondrosarcoma Cells after Treatment with 5-Aza-2′-Deoxycytidine Results in Increased Tumorigenicity

Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not completely known. To examine its effect on tumorigen...

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Detalles Bibliográficos
Autores principales: Hamm, Christopher A., Xie, Hehuang, Costa, Fabricio F., Vanin, Elio F., Seftor, Elisabeth A., Sredni, Simone T., Bischof, Jared, Wang, Deli, Bonaldo, Maria F., Hendrix, Mary J. C., Soares, Marcelo B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790612/
https://www.ncbi.nlm.nih.gov/pubmed/20019818
http://dx.doi.org/10.1371/journal.pone.0008340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790612/
https://www.ncbi.nlm.nih.gov/pubmed/20019818
http://dx.doi.org/10.1371/journal.pone.0008340

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