Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition

We have identified oleuropein (Ole) and hydroxytyrosol (HT) as a unique class of HIV-1 inhibitors from olive leaf extracts effective against viral fusion and integration. We used molecular docking simulation to study the interactions of Ole and HT with viral targets. We find that Ole and HT bind to...

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Detalles Bibliográficos
Autores principales: Lee-Huang, Sylvia, Huang, Philip Lin, Zhang, Dawei, Lee, Jae Wook, Bao, Ju, Sun, Yongtao, Chang, Young-Tae, Zhang, John, Huang, Paul Lee
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790717/
https://www.ncbi.nlm.nih.gov/pubmed/17275783
http://dx.doi.org/10.1016/j.bbrc.2007.01.071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790717/
https://www.ncbi.nlm.nih.gov/pubmed/17275783
http://dx.doi.org/10.1016/j.bbrc.2007.01.071

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