Demonstration of all-or-none loss of imprinting in mRNA expression in single cells

Loss of imprinting (LOI) is the reactivation of the silenced allele of an imprinted gene, leading to perturbation of monoallelic expression. We tested the hypothesis that LOI of PLAGL1, a representative maternally imprinted gene, occurs through an all-or-none process leading to a mixture of fully im...

Descripción completa

Detalles Bibliográficos
Autores principales: Diplas, Andreas I., Hu, Jianzhong, Lee, Men-Jean, Ma, Yula Y., Lee, Yin L., Lambertini, Luca, Chen, Jia, Wetmur, James G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790885/
https://www.ncbi.nlm.nih.gov/pubmed/19767614
http://dx.doi.org/10.1093/nar/gkp749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790885/
https://www.ncbi.nlm.nih.gov/pubmed/19767614
http://dx.doi.org/10.1093/nar/gkp749

Ejemplares similares