Cargando…

An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM

We have previously reported a natural GTAA deletion within an intronic splicing processing element (ISPE) of the ataxia telangiectasia mutated (ATM) gene that disrupts a non-canonical U1 snRNP interaction and activates the excision of the upstream portion of the intron. The resulting pre-mRNA splici...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pastor, Tibor, Talotti, Gabriele, Lewandowska, Marzena Anna, Pagani, Franco
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790898/ https://www.ncbi.nlm.nih.gov/pubmed/19773425 http://dx.doi.org/10.1093/nar/gkp778

Ejemplares similares

Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-Derived Intronic Splicing Enhancer Regulates ATM Aberrant Splicing
por: Pastor, Tibor, et al.
Publicado: (2011)

Functional studies on the ATM intronic splicing processing element
por: Lewandowska, Marzena A., et al.
Publicado: (2005)

Global control of aberrant splice-site activation by auxiliary splicing sequences: evidence for a gradient in exon and intron definition
por: Královičová, Jana, et al.
Publicado: (2007)

Isolation and characterization of post-splicing lariat–intron complexes
por: Yoshimoto, Rei, et al.
Publicado: (2009)

Introns regulate the production of ribosomal proteins by modulating splicing of duplicated ribosomal protein genes
por: Petibon, Cyrielle, et al.
Publicado: (2016)

Splicing-coupled 3′ end formation requires a terminal splice acceptor site, but not intron excision
por: Davidson, Lee, et al.
Publicado: (2013)

Alternative splicing and bioinformatic analysis of human U12-type introns
por: Chang, Wen-Cheng, et al.
Publicado: (2007)

Complex splicing control of the human Thrombopoietin gene by intronic G runs
por: Marcucci, Roberto, et al.
Publicado: (2007)

Antagonistic factors control the unproductive splicing of SC35 terminal intron
por: Dreumont, Natacha, et al.
Publicado: (2010)

Splicing of many human genes involves sites embedded within introns
por: Kelly, Steven, et al.
Publicado: (2015)

Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors
por: Culler, Stephanie J., et al.
Publicado: (2010)

Trans-splicing of the Ll.LtrB group II intron in Lactococcus lactis
por: Belhocine, Kamila, et al.
Publicado: (2007)

Extensive mis-splicing of a bi-partite plant mitochondrial group II intron
por: Elina, Helen, et al.
Publicado: (2010)

Structural accommodations accompanying splicing of a group II intron RNP
por: Dong, Xiaolong, et al.
Publicado: (2018)

Blocking of an intronic splicing silencer completely rescues IKBKAP exon 20 splicing in familial dysautonomia patient cells
por: Bruun, Gitte H, et al.
Publicado: (2018)

Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position
por: Shen, Manli, et al.
Publicado: (2012)

O-GlcNAc regulates gene expression by controlling detained intron splicing
por: Tan, Zhi-Wei, et al.
Publicado: (2020)

SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer
por: Buratti, Emanuele, et al.
Publicado: (2007)

Splicing of the Sinorhizobium meliloti RmInt1 group II intron provides evidence of retroelement behavior
por: Chillón, Isabel, et al.
Publicado: (2011)

Key features of the two-intron Saccharomyces cerevisiae gene SUS1 contribute to its alternative splicing
por: Hossain, Munshi Azad, et al.
Publicado: (2011)

A conserved 3′ extension in unusual group II introns is important for efficient second-step splicing
por: Stabell, Fredrik B., et al.
Publicado: (2009)

Alternative splicing of a group II intron in a surface layer protein gene in Clostridium tetani
por: McNeil, Bonnie A., et al.
Publicado: (2014)

Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing
por: Kong, Ka-Yiu Edwin, et al.
Publicado: (2014)

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing
por: Saha, Kaushik, et al.
Publicado: (2020)

Self-splicing of a group IIC intron: 5′ exon recognition and alternative 5′ splicing events implicate the stem–loop motif of a transcriptional terminator
por: Toor, Navtej, et al.
Publicado: (2006)

A trans-splicing group I intron and tRNA-hyperediting in the mitochondrial genome of the lycophyte Isoetes engelmannii
por: Grewe, Felix, et al.
Publicado: (2009)

Alu insertion variants alter mRNA splicing
por: Payer, Lindsay M, et al.
Publicado: (2019)

Alternate processing of Flt1 transcripts is directed by conserved cis-elements within an intronic region of FLT1 that reciprocally regulates splicing and polyadenylation
por: Thomas, Christie P., et al.
Publicado: (2010)

Tetrahymena thermophila and Candida albicans Group I intron-derived ribozymes can catalyze the trans-excision-splicing reaction
por: Dotson, P. Patrick, et al.
Publicado: (2008)

Group II intron in Bacillus cereus has an unusual 3′ extension and splices 56 nucleotides downstream of the predicted site
por: Stabell, Fredrik B., et al.
Publicado: (2007)

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing
por: Penn, Andrew C., et al.
Publicado: (2013)

Active 5΄ splice sites regulate the biogenesis efficiency of Arabidopsis microRNAs derived from intron-containing genes
por: Knop, Katarzyna, et al.
Publicado: (2017)

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
por: Humphrey, Jack, et al.
Publicado: (2020)

A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria
por: Kaspar, Benjamin J., et al.
Publicado: (2008)

The RAD52-like protein ODB1 is required for the efficient excision of two mitochondrial introns spliced via first-step hydrolysis
por: Gualberto, José M., et al.
Publicado: (2015)

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns
por: Doktor, Thomas Koed, et al.
Publicado: (2017)

Alu RNA fold links splicing with signal recognition particle proteins
por: Borovská, Ivana, et al.
Publicado: (2023)

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
por: Olthof, Anouk M, et al.
Publicado: (2021)

Improved detection of aberrant splicing using the Intron Jaccard Index
por: Scheller, Ines F., et al.
Publicado: (2023)

Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor
por: Alexander, Marina R., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_o9qhfa8jbvfqgujkj20pncil1i