The HSV-1 ICP27 RGG box specifically binds flexible, GC-rich sequences but not G-quartet structures

Herpes simplex virus 1 (HSV-1) protein ICP27, an important regulator for viral gene expression, directly recognizes and exports viral RNA through an N-terminal RGG box RNA binding motif, which is necessary and sufficient for RNA binding. An ICP27 N-terminal peptide, including the RGG box RNA binding...

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Detalles Bibliográficos
Autores principales: Corbin-Lickfett, Kara A., Chen, I-Hsiung Brandon, Cocco, Melanie J., Sandri-Goldin, Rozanne M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790906/
https://www.ncbi.nlm.nih.gov/pubmed/19783816
http://dx.doi.org/10.1093/nar/gkp793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790906/
https://www.ncbi.nlm.nih.gov/pubmed/19783816
http://dx.doi.org/10.1093/nar/gkp793

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