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Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering
The catalytic (C) and regulatory (R) subunits of protein kinase A are exceptionally dynamic proteins. Interactions between the R- and C-subunits are regulated by cAMP binding to the two cyclic nucleotide-binding domains in the R-subunit. Mammalian cells express four different isoforms of the R-subun...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791020/ https://www.ncbi.nlm.nih.gov/pubmed/19837668 http://dx.doi.org/10.1074/jbc.M109.059493 |