Cargando…

Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering

The catalytic (C) and regulatory (R) subunits of protein kinase A are exceptionally dynamic proteins. Interactions between the R- and C-subunits are regulated by cAMP binding to the two cyclic nucleotide-binding domains in the R-subunit. Mammalian cells express four different isoforms of the R-subun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Cecilia Y., Yang, Jie, Taylor, Susan S., Blumenthal, Donald K.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791020/ https://www.ncbi.nlm.nih.gov/pubmed/19837668 http://dx.doi.org/10.1074/jbc.M109.059493

Ejemplares similares

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

Atomic Resolution X-ray Structure of the Substrate Recognition Domain of Higher Plant Ribulose-bisphosphate Carboxylase/Oxygenase (Rubisco) Activase
por: Henderson, J. Nathan, et al.
Publicado: (2011)

X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions
por: Chen, Yafang, et al.
Publicado: (2015)

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation
por: Liu, Jinsong, et al.
Publicado: (2012)

Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3
por: Richart, Alexandria N., et al.
Publicado: (2012)

Solution Structure of the Severe Acute Respiratory Syndrome-Coronavirus Heptad Repeat 2 Domain in the Prefusion State
por: Hakansson-McReynolds, Susanna, et al.
Publicado: (2006)

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
por: Towler, Paul, et al.
Publicado: (2004)

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation
por: Steichen, Jon M., et al.
Publicado: (2012)

Solution NMR Structure of the Ca(2+)-bound N-terminal Domain of CaBP7: A REGULATOR OF GOLGI TRAFFICKING
por: McCue, Hannah V., et al.
Publicado: (2012)

Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy
por: Bagnéris, Claire, et al.
Publicado: (2015)

Solution NMR Analyses of the C-type Carbohydrate Recognition Domain of DC-SIGNR Protein Reveal Different Binding Modes for HIV-derived Oligosaccharides and Smaller Glycan Fragments
por: Probert, Fay, et al.
Publicado: (2013)

The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407
por: Anthony, Colin S., et al.
Publicado: (2010)

Low Resolution Structure and Dynamics of a Colicin-Receptor Complex Determined by Neutron Scattering
por: Clifton, Luke A., et al.
Publicado: (2012)

N-terminal Domain of Prion Protein Directs Its Oligomeric Association
por: Trevitt, Clare R., et al.
Publicado: (2014)

Mechanism of vaccinia viral protein B14–mediated inhibition of IκB kinase β activation
por: Tang, Qingyu, et al.
Publicado: (2018)

Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG
por: McDowell, Melanie A., et al.
Publicado: (2011)

Fibulin 5 Forms a Compact Dimer in Physiological Solutions
por: Jones, Richard P. O., et al.
Publicado: (2009)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain
por: Peng, Guiqing, et al.
Publicado: (2012)

Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation
por: DeSantis, Morgan E., et al.
Publicado: (2014)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Exceptionally high-affinity Ras binders that remodel its effector domain
por: McGee, John H., et al.
Publicado: (2018)

Molecular Mechanism of Z α1-Antitrypsin Deficiency
por: Huang, Xin, et al.
Publicado: (2016)

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain
por: Richter, Kirsten, et al.
Publicado: (2020)

Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs)
por: Wang, Hui, et al.
Publicado: (2011)

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
por: Kumar, Satish, et al.
Publicado: (2014)

Organization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking
por: Lee, Jennifer, et al.
Publicado: (2015)

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation
por: Robinson, Philip J., et al.
Publicado: (2017)

Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ
por: Somoza, John R., et al.
Publicado: (2015)

Stable Single α-Helices Are Constant Force Springs in Proteins
por: Wolny, Marcin, et al.
Publicado: (2014)

Mechanisms of Neutralization of a Human Anti-α-toxin Antibody
por: Oganesyan, Vaheh, et al.
Publicado: (2014)

Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains
por: Ma, Liang, et al.
Publicado: (2009)

Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function
por: Zhong, Ning, et al.
Publicado: (2009)

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation
por: Oroz, Javier, et al.
Publicado: (2021)

Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody
por: Prabakaran, Ponraj, et al.
Publicado: (2006)

Dissection Study on the Severe Acute Respiratory Syndrome 3C-like Protease Reveals the Critical Role of the Extra Domain in Dimerization of the Enzyme: DEFINING THE EXTRA DOMAIN AS A NEW TARGET FOR DESIGN OF HIGHLY SPECIFIC PROTEASE INHIBITORS
por: Shi, Jiahai, et al.
Publicado: (2004)

Inhibition of the Functional Interplay between Endoplasmic Reticulum (ER) Oxidoreduclin-1α (Ero1α) and Protein-disulfide Isomerase (PDI) by the Endocrine Disruptor Bisphenol A
por: Okumura, Masaki, et al.
Publicado: (2014)

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement
por: Miller, Ami, et al.
Publicado: (2012)

Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin
por: Mohan, Harihar Milaganur, et al.
Publicado: (2021)

Structural and Functional Investigations of Matrilin-1 A-domains Reveal Insights into Their Role in Cartilage ECM Assembly
por: Fresquet, Maryline, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_cdklml9178ura206r17i2k5et8