Phosphorylation of S776 and 14-3-3 Binding Modulate Ataxin-1 Interaction with Splicing Factors

Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, is responsible for spinocerebellar ataxia type 1. Requirements for developing the disease are polyQ expansion, nuclear localization and phosphorylation of S776. Using a combination of bioinformatics, cell and structural...

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Detalles Bibliográficos
Autores principales: de Chiara, Cesira, Menon, Rajesh P., Strom, Molly, Gibson, Toby J., Pastore, Annalisa
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791216/
https://www.ncbi.nlm.nih.gov/pubmed/20037628
http://dx.doi.org/10.1371/journal.pone.0008372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791216/
https://www.ncbi.nlm.nih.gov/pubmed/20037628
http://dx.doi.org/10.1371/journal.pone.0008372

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