Optimizing substitution matrix choice and gap parameters for sequence alignment

BACKGROUND: While substitution matrices can readily be computed from reference alignments, it is challenging to compute optimal or approximately optimal gap penalties. It is also not well understood which substitution matrices are the most effective when alignment accuracy is the goal rather than ho...

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Detalles Bibliográficos
Autor principal: Edgar, Robert C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791778/
https://www.ncbi.nlm.nih.gov/pubmed/19954534
http://dx.doi.org/10.1186/1471-2105-10-396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791778/
https://www.ncbi.nlm.nih.gov/pubmed/19954534
http://dx.doi.org/10.1186/1471-2105-10-396

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