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Optimizing substitution matrix choice and gap parameters for sequence alignment
BACKGROUND: While substitution matrices can readily be computed from reference alignments, it is challenging to compute optimal or approximately optimal gap penalties. It is also not well understood which substitution matrices are the most effective when alignment accuracy is the goal rather than ho...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791778/ https://www.ncbi.nlm.nih.gov/pubmed/19954534 http://dx.doi.org/10.1186/1471-2105-10-396 |