Aging Reveals a Role for Nigral Tyrosine Hydroxylase ser31 Phosphorylation in Locomotor Activity Generation

BACKGROUND: Tyrosine hydroxylase (TH) regulates dopamine (DA) bioavailability. Its product, L-DOPA, is an established treatment for Parkinson's disease (PD), suggesting that TH regulation influences locomotion. Site-specific phosphorylation of TH at ser31 and ser40 regulates activity. No direct...

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Detalles Bibliográficos
Autores principales: Salvatore, Michael F., Pruett, Brandon S., Spann, Sandy L., Dempsey, Charles
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791868/
https://www.ncbi.nlm.nih.gov/pubmed/20037632
http://dx.doi.org/10.1371/journal.pone.0008466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791868/
https://www.ncbi.nlm.nih.gov/pubmed/20037632
http://dx.doi.org/10.1371/journal.pone.0008466

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