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A Novel Protein Phosphatase 1-Dependent Spindle Checkpoint Silencing Mechanism
The spindle checkpoint is a surveillance system acting in mitosis to delay anaphase onset until all chromosomes are properly attached to the mitotic spindle [1, 2]. When the checkpoint is activated, the Mad2 and Mad3 proteins directly bind and inhibit Cdc20, which is an essential activator of an E3...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791888/ https://www.ncbi.nlm.nih.gov/pubmed/19592249 http://dx.doi.org/10.1016/j.cub.2009.05.060 |