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Detection of Sequential Polyubiquitylation on a Millisecond Time-Scale
The pathway by which ubiquitin chains are generated on substrate via a cascade of enzymes consisting of an E1, E2 and E3 remains unclear. Multiple distinct models involving chain assembly on E2 or substrate have been proposed. However, the speed and complexity of the reaction have precluded direct e...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791906/ https://www.ncbi.nlm.nih.gov/pubmed/19956254 http://dx.doi.org/10.1038/nature08595 |