Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

BACKGROUND: MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes. METHODS: Gene expression was determined by real-time PCR. The effect of each...

Descripción completa

Detalles Bibliográficos
Autores principales: Tardif, Ginette, Hum, David, Pelletier, Jean-Pierre, Duval, Nicolas, Martel-Pelletier, Johanne
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792220/
https://www.ncbi.nlm.nih.gov/pubmed/19948051
http://dx.doi.org/10.1186/1471-2474-10-148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792220/
https://www.ncbi.nlm.nih.gov/pubmed/19948051
http://dx.doi.org/10.1186/1471-2474-10-148

Ejemplares similares