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A Study on Improvement of Solubility of Rofecoxib and its effect on Permeation of Drug from Topical Formulations
Rofecoxib, a practically insoluble cox-2 selective nonsteroidal antiinflammatory agent was subjected to improvement in solubility by preparing its binary mixtures with β cyclodextrin using various methods such as physical mixing, co-grinding, kneading with aqueous methanol and co-evaporation from me...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792560/ https://www.ncbi.nlm.nih.gov/pubmed/20046772 http://dx.doi.org/10.4103/0250-474X.44595 |