Increased Light Exposure Alleviates One Form of Photoreceptor Degeneration Marked by Elevated Calcium in the Dark

BACKGROUND: In one group of gene mutations that cause photoreceptor degeneration in human patients, guanylyl cyclase is overactive in the dark. The ensuing excess opening of cGMP-gated cation channels causes intracellular calcium to rise to toxic levels. The Y99C mutation in guanylate cyclase-activa...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoqing, Pawlyk, Basil S., Adamian, Michael, Olshevskaya, Elena V., Dizhoor, Alexander M., Makino, Clint L., Li, Tiansen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793020/
https://www.ncbi.nlm.nih.gov/pubmed/20041177
http://dx.doi.org/10.1371/journal.pone.0008438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793020/
https://www.ncbi.nlm.nih.gov/pubmed/20041177
http://dx.doi.org/10.1371/journal.pone.0008438

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