Molecular dynamics simulations and coupled nucleotide substitution experiments indicate the nature of A·A base pairing and a putative structure of the coralyne-induced homo-adenine duplex

Coralyne is an alkaloid drug that binds homo-adenine DNA (and RNA) oligonucleotides more tightly than it does Watson–Crick DNA. Hud’s laboratory has shown that poly(dA) in the presence of coralyne forms an anti-parallel duplex, however attempts to determine the structure by NMR spectroscopy and X-ra...

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Detalles Bibliográficos
Autores principales: Joung, In Suk, Persil Çetinkol, Özgül, Hud, Nicholas V., Cheatham, Thomas E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794157/
https://www.ncbi.nlm.nih.gov/pubmed/19850721
http://dx.doi.org/10.1093/nar/gkp730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794157/
https://www.ncbi.nlm.nih.gov/pubmed/19850721
http://dx.doi.org/10.1093/nar/gkp730

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