Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase α4 helix

HIV-1 integrase integrates retroviral DNA through 3′-processing and strand transfer reactions in the presence of a divalent cation (Mg(2+) or Mn(2+)). The α4 helix exposed at the catalytic core surface is essential to the specific recognition of viral DNA. To define group determinants of recognition...

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Detalles Bibliográficos
Autores principales: Hobaika, Zeina, Zargarian, Loussine, Boulard, Yves, Maroun, Richard G., Mauffret, Olivier, Fermandjian, Serge
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794180/
https://www.ncbi.nlm.nih.gov/pubmed/19808934
http://dx.doi.org/10.1093/nar/gkp824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794180/
https://www.ncbi.nlm.nih.gov/pubmed/19808934
http://dx.doi.org/10.1093/nar/gkp824

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