Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

Numerous regulatory genes have G-rich regions that can potentially form quadruplex structures, possibly playing a role in transcription regulation. We studied a G-rich sequence in the BCL2 gene 176-bp upstream of the P1 promoter for G-quadruplex formation. Using circular dichroism (CD), thermal dena...

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Detalles Bibliográficos
Autores principales: Onyshchenko, Mykola I., Gaynutdinov, Timur I., Englund, Ethan A., Appella, Daniel H., Neumann, Ronald D., Panyutin, Igor G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794188/
https://www.ncbi.nlm.nih.gov/pubmed/19820116
http://dx.doi.org/10.1093/nar/gkp840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794188/
https://www.ncbi.nlm.nih.gov/pubmed/19820116
http://dx.doi.org/10.1093/nar/gkp840

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