Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints

Vectors based on the adeno-associated virus are attractive and versatile vehicles for in vivo gene transfer. The virus capsid is the primary interface with the cell that defines many pharmacological, immunological and molecular properties. Determinants of these interactions are often restricted to a...

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Detalles Bibliográficos
Autores principales: Vandenberghe, Luk H., Breous, Ekaterina, Nam, Hyun-Joo, Gao, Guangping, Xiao, Ru, Sandhu, Arbans, Johnston, Julie, Debyser, Zeger, Agbandje-McKenna, Mavis, Wilson, James M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795093/
https://www.ncbi.nlm.nih.gov/pubmed/19727141
http://dx.doi.org/10.1038/gt.2009.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795093/
https://www.ncbi.nlm.nih.gov/pubmed/19727141
http://dx.doi.org/10.1038/gt.2009.101

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