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Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints
Vectors based on the adeno-associated virus are attractive and versatile vehicles for in vivo gene transfer. The virus capsid is the primary interface with the cell that defines many pharmacological, immunological and molecular properties. Determinants of these interactions are often restricted to a...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795093/ https://www.ncbi.nlm.nih.gov/pubmed/19727141 http://dx.doi.org/10.1038/gt.2009.101 |