Steered Molecular Dynamics Simulations Reveal the Likelier Dissociation Pathway of Imatinib from Its Targeting Kinases c-Kit and Abl

Development of small molecular kinase inhibitors has recently been the central focus in drug discovery. And type II kinase inhibitors that target inactive conformation of kinases have attracted particular attention since their potency and selectivity are thought to be easier to achieve compared with...

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Detalles Bibliográficos
Autores principales: Yang, Li-Jun, Zou, Jun, Xie, Huan-Zhang, Li, Lin-Li, Wei, Yu-Quan, Yang, Sheng-Yong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795779/
https://www.ncbi.nlm.nih.gov/pubmed/20041122
http://dx.doi.org/10.1371/journal.pone.0008470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795779/
https://www.ncbi.nlm.nih.gov/pubmed/20041122
http://dx.doi.org/10.1371/journal.pone.0008470

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