Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

The Lats2 tumor suppressor protein has previously been implicated in promoting p53 activation in response to mitotic apparatus stress, by preventing Mdm2-driven p53 degradation. We now report that Lats2 also plays a role in an ATR-Chk1-mediated stress checkpoint in response to oncogenic H-Ras. Activ...

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Detalles Bibliográficos
Autores principales: Aylon, Yael, Yabuta, Norikazu, Besserglick, Hila, Buganim, Yossi, Rotter, Varda, Nojima, Hiroshi, Oren, Moshe
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795787/
https://www.ncbi.nlm.nih.gov/pubmed/19855428
http://dx.doi.org/10.1038/onc.2009.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795787/
https://www.ncbi.nlm.nih.gov/pubmed/19855428
http://dx.doi.org/10.1038/onc.2009.270

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