Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression

Genome-wide associations between single-nucleotide polymorphisms and clinical traits were simultaneously conducted using penalized orthogonal-components regression. This method was developed to identify the genetic variants controlling phenotypes from a massive number of candidate variants. By inves...

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Detalles Bibliográficos
Autores principales: Lin, Yanzhu, Zhang, Min, Wang, Libo, Pungpapong, Vitara, Fleet, James C, Zhang, Dabao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795917/
https://www.ncbi.nlm.nih.gov/pubmed/20018010
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author Lin, Yanzhu
Zhang, Min
Wang, Libo
Pungpapong, Vitara
Fleet, James C
Zhang, Dabao
author_facet Lin, Yanzhu
Zhang, Min
Wang, Libo
Pungpapong, Vitara
Fleet, James C
Zhang, Dabao
author_sort Lin, Yanzhu
collection PubMed
description Genome-wide associations between single-nucleotide polymorphisms and clinical traits were simultaneously conducted using penalized orthogonal-components regression. This method was developed to identify the genetic variants controlling phenotypes from a massive number of candidate variants. By investigating the association between all single-nucleotide polymorphisms to the phenotype of antibodies against cyclic citrullinated peptide using the rheumatoid arthritis data provided by Genetic Analysis Workshop 16, we identified genetic regions which may contribute to the pathogenesis of rheumatoid arthritis. Bioinformatic analysis of these genomic regions showed most of them harbor protein-coding gene(s).
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spelling pubmed-27959172009-12-18 Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression Lin, Yanzhu Zhang, Min Wang, Libo Pungpapong, Vitara Fleet, James C Zhang, Dabao BMC Proc Proceedings Genome-wide associations between single-nucleotide polymorphisms and clinical traits were simultaneously conducted using penalized orthogonal-components regression. This method was developed to identify the genetic variants controlling phenotypes from a massive number of candidate variants. By investigating the association between all single-nucleotide polymorphisms to the phenotype of antibodies against cyclic citrullinated peptide using the rheumatoid arthritis data provided by Genetic Analysis Workshop 16, we identified genetic regions which may contribute to the pathogenesis of rheumatoid arthritis. Bioinformatic analysis of these genomic regions showed most of them harbor protein-coding gene(s). BioMed Central 2009-12-15 /pmc/articles/PMC2795917/ /pubmed/20018010 Text en Copyright ©2009 Lin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Lin, Yanzhu
Zhang, Min
Wang, Libo
Pungpapong, Vitara
Fleet, James C
Zhang, Dabao
Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
title Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
title_full Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
title_fullStr Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
title_full_unstemmed Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
title_short Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
title_sort simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795917/
https://www.ncbi.nlm.nih.gov/pubmed/20018010
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