Combining least absolute shrinkage and selection operator (LASSO) and principal-components analysis for detection of gene-gene interactions in genome-wide association studies

Variable selection in genome-wide association studies can be a daunting task and statistically challenging because there are more variables than subjects. We propose an approach that uses principal-component analysis (PCA) and least absolute shrinkage and selection operator (LASSO) to identify gene-...

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Detalles Bibliográficos
Autores principales: D'Angelo, Gina M, Rao, DC, Gu, C Charles
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795963/
https://www.ncbi.nlm.nih.gov/pubmed/20018056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795963/
https://www.ncbi.nlm.nih.gov/pubmed/20018056

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