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Evaluation of single-nucleotide polymorphism imputation using random forests

Genome-wide association studies (GWAS) have helped to reveal genetic mechanisms of complex diseases. Although commonly used genotyping technology enables us to determine up to a million single-nucleotide polymorphisms (SNPs), causative variants are typically not genotyped directly. A favored approac...

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Detalles Bibliográficos
Autores principales: Schwarz, Daniel F, Szymczak, Silke, Ziegler, Andreas, König, Inke R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795966/
https://www.ncbi.nlm.nih.gov/pubmed/20018059